Possible natural fluid pathways from gravity pseudo-tomography in the geothermal fields of Northern Alsace (Upper Rhine Graben)

Background This study aims on investigating the regional flow field of the Soultz and adjacent geothermal fields located on the western side of the central Upper Rhine Graben and thus to provide insight into the origin of the 70% of the geothermal fluid coming from the regional inflow in the deep reservoir of the Soultz site. In an integrative approach, we consolidate conceptual models on fluid flow in the central Upper Rhine Graben. Methods Based on a 3D geological model and a new 3D temperature interpolation, we tackle the relation between tectonic structures and the occurrence of advection/convection along favourably oriented fault zones. Using sequential Butterworth filters, we study the distribution of negative residual anomalies in a pseudo-tomography down to a depth of about 6 to 8 km. Results We derived N-S-striking V-shaped negative anomalies that are consistent with the orientation of fault zones revealing major temperature anomalies to their east. Conclusions Following the concept of negative anomalies revealing zones of increased fracture porosity, and in agreement with fluid-chemistry, our findings suggest infiltration of meteoric water through the graben boundary fault and along preferential flow pathways that merge at intermediate depth. Up-flow of thermal water mixed most likely with brine from the deeper eastern part of the graben occurs along W-dipping typically rather steep structures

Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology

A recent genome-wide association meta-analysis for Alzheimer's disease (AD) identified 19 risk loci (in addition to APOE) in which the functional genes are unknown. Using Drosophila, we screened 296 constructs targeting orthologs of 54 candidate risk genes within these loci for their ability to modify Tau neurotoxicity by quantifying the size of >6000 eyes. Besides Drosophila Amph (ortholog of BIN1), which we previously implicated in Tau pathology, we identified p130CAS (CASS4), Eph (EPHA1), Fak (PTK2B) and Rab3-GEF (MADD) as Tau toxicity modulators. Of these, the focal adhesion kinase Fak behaved as a strong Tau toxicity suppressor in both the eye and an independent focal adhesion-related wing blister assay. Accordingly, the human Tau and PTK2B proteins biochemically interacted in vitro and PTK2B co-localized with hyperphosphorylated and oligomeric Tau in progressive pathological stages in the brains of AD patients and transgenic Tau mice. These data indicate that PTK2B acts as an early marker and in vivo modulator of Tau toxicity

Full Wave Inversion of OVSP Seismic Data for Faults Delineation and Characterization in Granite Context

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